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Insulin aggravates free fatty acid-induced hepatocyte cell death by activation of CD95 death receptor pathways in liver

R Reinehr, A Sommerfeld, D Häussinger · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
1079489
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
R Reinehr, A Sommerfeld, D Häussinger
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295796

Zusammenfassung

Introduction: Free fatty acids (FFA) induce lipoapoptosis in hepatocytes in a JNK-dependent but death receptor-independent way.1 Insulin has been reported to induce EGFR activation in liver.2 Since JNK-dependent and EGFR-mediated CD95-Tyr-P is a crucial step in CD95 activation,3 the aim of the study was to elucidate whether addition of insulin may aggravate FFA-induced cell death by activation of CD95. Methods: Studies were performed in hepatocytes isolated from rats and the CD95-k.o.-mouse. Results: Caprylate (C8; 200µM) as well as palmitate (C16 200µM) induced within 18h apoptosis in hepatocytes as measured by…

Schlagworte

CD95 Hyperinsulinemie NASH free fatty acids Association Apoptosis Caprylate Zeitschrift für Gastroenterologie