CareLit Fachartikel

Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

W Hu, YA Nevzorova, U Haas, P Sicinski, M Barbacid, C Trautwein, C Liedtke · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
1079490
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
W Hu, YA Nevzorova, U Haas, P Sicinski, M Barbacid, C Trautwein, C Liedtke
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295806

Zusammenfassung

Canonical cell cycle activation in quiescent hepatocytes prior to liver regeneration involves complex formation of cyclin E1 (CcnE1) with its associated cyclin-dependent kinase 2 (Cdk2), thereby initiating DNA-replication (S-phase). Surprisingly, we previously found that unique loss of either Cdk2 or CcnE1 does not affect hepatocyte proliferation after partial hepatectomy (PH). Thus, the aim of the current study was to evaluate the compensatory mechanisms driving liver regeneration in absence of Cdk2. Formation of the pre-replication complex (pre-RC) and loading of minichromosome maintenance (MCM) proteins on ch…

Schlagworte

After Cyclin-Dependent Kinase 2 Chromatin Cyclin A Affect Zeitschrift für Gastroenterologie