Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver
J Wanninger, R Walter, S Bauer, TS Weiss, K Eisinger, C Hellerbrand, A Schäffler, A Higuchi, K Walsh, C Buechler · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Objective: Chemokine-like receptor 1 (CMKLR1) ligands chemerin and resolvin E1 are suggested to have a role in non-alcoholic fatty liver disease (NAFLD). Here, expression of CMKLR1 in liver cells and NAFLD was studied. Methods: Primary human hepatocytes and liver of patients with and without liver steatosis were used. Human liver tissue was obtained according to the guidelines of the charitable state-controlled foundation Human Tissue & Cell Research (HTCR) with the patient's informed consent. To induce NASH mice were fed a methionine-choline deficient diet for 6 weeks. Results: CMKLR1 was detected in primary hu…
