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PRETREATMENT OF HUMANIZED uPA/SCID MICE WITH INTERFERON ALPHA STRONGLY INHIBITS THE ESTABLISHMENT OF HBV INFECTION

T Volz, M Lütgehetmann, L Allweiss, AW Lohse, J Petersen, M Dandri · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
1079504
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Jahr
2012
Publikation
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
T Volz, M Lütgehetmann, L Allweiss, AW Lohse, J Petersen, M Dandri
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295946

Zusammenfassung

Activation of innate host defenses including the interferon signaling is critical tocounteract viral infections. A better understanding of how IFN-a) can affect HBV inthe early phases of infection may provide new clues about the mechanisms of chronicinfection and also support the design of improved therapeutic approaches. Aim of thisstudy was to investigate whether pegylated interferon alpha (peg-IFN-a) treatmentcould hinder the establishment of HBV infection in vivo. Methods: Human liver chimericuPA/SCID mice received peg-IFN-a) (25 ng/gr, i.p., twice per week) one week beforeand 2 weeks post HBV infection (p.i…

Schlagworte

HBV Peg-IFN uPA/SCID Defense Mechanisms Affect Zeitschrift für Gastroenterologie