Naturally occurring, tumor-specific CD8+ T cells in patients with hepatocellular carcinoma display a clear immunodominance
T Flecken, N Schmidt, S Hild, O Drognitz, DA Price, C Neumann-Haefelin, HC Spangenberg, R Thimme · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and ranks third in mortality. This is partly due to a limited number of available therapeutic approaches. Since several studies found that the immune response directed against the tumor is associated with prognosis, immunotherapy is a potential future way of treatment. To develop such immune-based therapies, a better understanding of the natural immune response against HCC is obligatory. To address this issue, we used overlapping peptides covering the entire sequence of four prominent tumor-associated antigens (TAAs) in HCC, i.e. α-fetoprot…
