Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells
S Lange, J Lampe, M Zimmermann, S Bossow, W Neubert, NP Malek, M Bitzer, UM Lauer · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Today, cholangiocarcinoma (CC) only is curable in early stages by complete surgical resection. Therapeutics employing new methods of action are desperately needed. Virotherapeutic viruses employed in clinical studies spread preferentially in cancer cells and virus-mediated cell killing can be enhanced by expression of suicide genes. Methods: A measles vaccine virus (MeV) vector (Schwarz strain) expressing SCD (fusion protein of yeast cytosine deaminase and yeast uracil phospho¬ribosyltransferase which converts the prodrug 5-Fluorocytosine to 5-Fluorouracile (approved chemo¬therapeutic) and subseque…
