Role of autophagy in the development of amiodarone induced pulmonary fibrosis
P Mahavadi, I Henneke, L Knudsen, R Chambers, M Ochs, M Korfei, P Markart, W Seeger, C Ruppert, A Guenther · Pneumologie · 2011 · Heft 12
Bibliografische Angaben
Zusammenfassung
Rationale: Amiodarone (AD) is an anti arrhythmic drug, and is well known for its vasodilatory properties. But this drug is limited by its potential side effects. Severe pulmonary toxicity is reported in patients receiving amiodarone even at low doses, with the most common histological finding being chronic interstitial pneumonia. Amiodarone induced pulmonary toxicity was studied in experimental rat model where apoptosis of alveolar epithelial cells type II (AECII) was reported. However, the molecular mechanisms underlying amiodarone induced pulmonary fibrosis remain unknown. In addition, amiodarone is known to i…
