PAR-2 depletion protects against development of pulmonary hypertension
G Kwapiszewska, P Markart, LM Marsh, B Dahal, RT Schermuly, C Taube, A Meinhardt, HA Ghofrani, M Steinhoff, W Seeger, KT Preissner, N Weißmann, M Wygrecka · Pneumologie · 2012 · Heft 02
Bibliografische Angaben
Zusammenfassung
Background: A hallmark of the vascular remodeling process underlying pulmonary hypertension (PH) is the aberrant proliferation and migration of pulmonary artery smooth muscle cells (PASMC). Accumulating evidence suggests that mast cell mediators play a role in the pathogenesis of PH. Therefore, in the present study we investigated the importance of protease-activated receptor (PAR)-2 and its ligand mast cell tryptase in the development of PH. Results: Our results revealed strong increase in PAR-2 and tryptase expression in the lungs of idiopathic pulmonary arterial hypertension (IPAH) patients, mice exposed to h…
