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Macrolides inhibit cytokine production by alveolar macrophages in bronchiolitis obliterans organizing pneumonia

M Cai, F Bonella, H Dai, J Guzman, U Costabel · Pneumologie · 2012 · Heft 02

Dokument
1079724
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
M Cai, F Bonella, H Dai, J Guzman, U Costabel
Ausgabe
Heft 02 / 2012
Seiten
–
Erschienen: 2012-02-23 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0032-1302796

Zusammenfassung

Background: Bronchiolitis obliterans organizing pneumonia (BOOP) is a distinct clinicopathological entity histologically characterized by intra-alveolar granulation tissue and absence of extensive fibrotic lesions. Effective macrolide treatment of BOOP has been reported anecdotally. Objectives: This study aimed to investigate whether alveolar macrophages (AMs) produce aberrant proinflammatory cytokines in BOOP and whether this can be inhibited by clarithromycin (CAM) or azithromycin (AZM). Methods: AMs collected by bronchoalveolar lavage (BAL) from 6 BOOP patients and 8 non-ILD controls were cultured for 24 hour…

Schlagworte

Cytokines Bronchiolitis Obliterans Bronchiolitis Bronchoalveolar Lavage Clarithromycin Dexamethasone Azithromycin Chemokine Tumor Cytokine Pneumologie