Evaluation of Raman spectroscopic mapping for the detection of cervical intraepithelial neoplasia

Objektive: Cervical cancer is the second most frequent cancer among women worldwide. For the early detection of precancerous tissue, i.e., cervical intraepithelial neoplasia (CIN), lposcopically-guided biopsy and a following histological analysis is currently the gold standard with fairly acceptable sensitivity and specificity. However, colposcopy requires a physician to be highly experienced and histopathological results can be conflicting due to high levels of inter- and intra-observer discrepancies. The development of a method for the non-invasive, objective detection of precancerous lesions in real-time has…