A microdeletion within a QTL hotspot on distal mouse chromosome 1 disrupts the Ifi202b gene and modulates metabolic and neuronal phenotypes
H Vogel, T Kanzleiter, S Scherneck, V Benz, R Kluge, M Blüher, D Montag, HG Joost, A Schürmann · Diabetologie und Stoffwechsel · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Objectives: The New Zealand Obese (NZO) mouse develops a polygenic disease pattern of obesity, insulin resistance, and dyslipoproteinemia resembling the human metabolic syndrome. By positional cloning we have recently discovered two genes (Tbc1d1, Zfp69) to participate in the development of the disease. In an outcross population of NZO and lean C57BL/6 (B6) mice we identified a major obesity QTL on distal chromosome 1 responsible for a body weight increment of 13g in week 22. Methods: The conventional strategy of positional cloning, including generation of congenic lines with the lean B6 background, was used to…
