Transient increase in mitochondrial oxidative capacity during the development of insulin resistance in a mouse model of non-alcoholic fatty liver
T Jelenik, G Séquaris, J Szendrödi, J Kotzka, E Phielix, B Knebel, P Nowotny, HJ Partke, D Müller-Wieland, M Roden · Diabetologie und Stoffwechsel · 2012 · Heft 08
Bibliografische Angaben
Zusammenfassung
Non-alcoholic fatty liver (NAFL) and ectopic lipid storage in skeletal muscle have been associated with insulin resistance and abnormal mitochondrial function in obesity and type 2 diabetes. The underlying causal relationships are yet unclear. The aim of this study was to determine the role of mitochondrial function during the development of lipid-induced NAFL and insulin resistance. We examined liver and muscle metabolism in 18- and 36-weeks-old female mice with secondary NAFL due to adipose tissue-specific overexpression of the sterol regulatory-element binding protein-1c (aP2-SREBP-1c: AP2; n=6–7) and in age-…
