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Studies towards targeting Thymic Stromal Lymhopoietin (TSLP) and STAT (Signal Transducers and Activators of Transcription) pathways for therapeutic amelioration of Asthma bronchia…

N Ranjan, A Wohlmann, A Borowski, K Gautam, K Friedrich · Pneumologie · 2012 · Heft 05

Dokument
1080166
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
N Ranjan, A Wohlmann, A Borowski, K Gautam, K Friedrich
Ausgabe
Heft 05 / 2012
Seiten
–
Erschienen: 2012-05-31 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0032-1315486

Zusammenfassung

Asthma is a globally prevalent chronic, inflammatory immune hyper-responsiveness, foreseen as a major health concern by WHO. It is now known to be linked to a dysregulated Th2 repertoire of cytokines (IL-4, IL-5, IL-10, IL-13). The disease is characterized by variable airway obstruction, hyperresponsiveness, inflammation, remodeling. desquamation of the bronchial epithelial layer, goblet cell hyperplasia and thickening of submucosa. Recent advances in deciphering the molecular mechanisms of Asthma have led us to exploit the potential of cytokine TSLP, the TSLP receptor and its signal transduction as prospective…

Schlagworte

Asthma Cytokine Airway Obstruction Dendritic Cells Antibodies Cytokines Axis Asthma bronchiale Pneumologie