CareLit Fachartikel
Elastase inhibition is not a requirement for the anti-inflammatory effects of Alpha-1 Antitrypsin: studies in neutrophil models
E Frenzel, N Aggarwal, S Wrenger, T Welte, S Janciauskiene · Pneumologie · 2012 · Heft 05
Dokument
1080167
CareLit-ID
Jahr
2012
Publikation
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Zusammenfassung
As an acute phase protein, alpha-antitrypsin (AAT) is thought to play an important role in limiting host tissue injury by proteases released from activated myeloid cells, specifically neutrophil elastase (NE). The clinical importance of AAT is highlighted in individuals with inherited deficiency in circulating AAT who have an increased susceptibility to early onset pulmonary emphysema, chronic bronchitis, bronchiectasis, and liver diseases. Administration of exogenous human plasma-derived AAT is used in various animal models to test the value of AAT augmentation therapy. Unrelated to emphysema models, administra…
Schlagworte
Blood
Bronchiectasis
Allografts
Bronchitis
Apoptosis
Cytokines
After
Transplantation
Alpha-1-Antitrypsin
alpha 1-Antitrypsin
Pneumologie
