Establishing of a pure entothelial cell culture from differentiating murine embryonic stem cells

Endothelium is of essential importance for the maintenance of vessel function. Endothelial dysfunction is considered as a key event in the pathology of cardiovascular diseases. Newer studies have proven that progressive ischemic dysfunction and organ damage can be prevented and restored by new therapeutic strategies like cell-based therapy. These attempts encompass application of autologous progenitor cells derived from peripheral blood or bone marrow. The accurate definition and origin of progenitor cells and their function during vessel recovery still remain as unsolved issues. Peripheral blood contains only a…