A potential role of high mobility group box-1 (HGMB1) in inflammatory vascular remodelling

Pulmonary hypertension (PH) is a life threatening disease characterised by a progressive remodelling of the pulmonary arteries. Recently, inflammatory processes have been implicated in the development and progression of PH. High mobility group box-1 (HGMB1) is a nuclear protein that acts to stabilise nucleosome formation and regulates transcription. Extracellularly, HGMB1 has an important role in mediating the inflammatory response, acting not only as an endogenous danger signal but also as a chemoattractant. Additionally, HMGB1 has been implicated in several pathological conditions including rheumatic disease,…