CareLit Fachartikel
DNA Damaging Drugs in the Treatment of Glioblastoma: HR, Apoptosis, Autophagy and Senescence
A Knizhnik, S Quiros, C Barckhausen, WP Roos, B Kaina · Klinische Pädiatrie · 2012 · Heft 11
Dokument
1080248
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Alkylating agents, notably temozolomide, are 1st line therapeutics for the treatment of glioma. These agents induce different DNA lesions. One of the DNA adducts is O6-methylguanine (O6MeG), which is a powerful cytotoxic lesion. The damage is repaired by the suicide enzyme alkyltransferase (MGMT), which is a very important defense mechanism and marker of alkylating drug resistance. We have studied in detail how apoptosis is induced following O6MeG in glioma cells. We have shown that O6MeG triggered cell death is executed via the death receptor and the mitochondrial damage pathway, involving DNA double-strand bre…
Schlagworte
Apoptosis
Autophagy
Alkylating Agents
Drug Resistance
Work
ACNU
Klinische Pädiatrie
