Does the measurement of the difference of resistive indices in spleen and kidney (DI-RISK) allow a selective assessment of chronic kidney injury?

gunnar.heine@uks.eu Purpose: To assess if calculation of the difference of resistance indices (RI) in spleen and kidney (DI-RISK) would be a more specific ultrasound marker of intra-renal parenchymal damage than measuring intra-renalRI alone. Materials and Methods: We defined standard values for renal RI, splenic RI and DI-RISK values in 152 healthy subjects; we assessed carotid intima media-thickness (IMT) as a marker of systemic vascular disease. Next, we measured these ultrasound parameters and collected echocardiographic data in 290 patients suffering from chronic kidney disease stage 2–4, in order to evalua…