A novel armed oncolytic measles vaccine virus for the treatment of cholangiocarcinoma
S Lange, J Lampe, M Zimmermann, S Bossow, W Neubert, NP Malek, M Bitzer, UM Lauer · Zeitschrift für Gastroenterologie · 2012 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Up to now, cholangiocarcinoma (CC) only is curable in early stages by complete surgical resection. Therapeutics employing new methods of action are desperately needed. Virotherapeutic viruses, which are already employed in clinical studies, spread preferentially in cancer cells and virus-mediated cell killing can be enhanced by expression of suicide genes. Methods: A measles vaccine virus (MeV) vector (Schwarz strain) expressing SCD (fusion protein of yeast cytosine deaminase and uracil phosphoribosyltransferase which converts the prodrug 5-Fluorocytosine to 5-Fluorouracil (approved chemotherapeuti…
