Diagnostik und Therapie der CMML

CMML is the most frequent entity among myelodysplastic/myeloproliferative syndromes according to the WHO classification [1]. CMML is a clonal disease. CMML is a rare (˜1.5 cases/100,000 per year) clonal disorder of the elderly (mean age ˜70 years) characterized by persistent monocytosis. Symptoms, when present, are the consequences of cytopenias (notably anemia, which is invalidating in a third of patients), and/or of extramedullary hematopoiesis, notably splenomegaly but also hepatomegaly, skin infiltration and serous (notably pleural) effusions. Autoimmune manifestations can be associated to CMML. Patient surv…