Notch signaling participates in liver fibrosis
HL Weng, Y Liu, Z Shen, MY Xu, R Liebe, V Zimmer, F Lammert, P ten Dijke, LG Lu, Y Li, S Dooley · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aims: Humans have five Notch ligands (Jagged1, Jagged2, Delta like ligand (Dll)1, Dll3 and Dll4) and four receptors (Notch1, 2, 3 and 4). Mutations of Jagged1 or Notch2 lead to Alagille syndrome, a disease characterized by defective development of intralobular bile ducts. Alternatively, Notch signaling drives hepatic progenitor cells differentiating into cholangiocytes during acute and chronic hepatic regeneration. It is not known to date whether Notch family members a play role in liver fibrosis. Here we investigated effects of Notch ligands in HBV-infected patients and experimental models. Metho…
