Single-dose radiosurgical treatment for hepatic metastases – Therapeutic outcome of 178 treated lesions from a single institution

Aims: Local ablative therapies such as stereotactically guided single-dose radiotherapy or helical intensity-modulated radiotherapy (tomotherapy) with high single-doses are successfully applied in many centers in patients with liver metastasis not suitable for surgical resection. This study presents results from more than 10 years of clinical experience and evaluates long-term outcome and efficacy of this therapeutic approach. Patients and Methods: From 1997 to 2009 a total of 178 intrahepatic tumors of 113 patients were irradiated with single doses of 10 to 30Gy (median dose 24Gy, 107 patients) or using a three…