Spatial orientation deficits in mild cognitive impairment
A Zwergal, F Schöberl, G Kugler, S Kohlbecher, J Engler, G Xiong, T Brandt, M Dieterich, M Dichgans, K Bürger, E Schneider, C la Fougere, K Jahn · Klinische Neurophysiologie · 2013 · Heft 03
Bibliografische Angaben
Zusammenfassung
Aim: Deficits in spatial orientation and navigation appear early in the course of Alzheimer's dementia. In the present study spatial orientation strategy and brain activation during real navigation were compared in patients with amnestic mild cognitive impairment (MCI) and age-matched healthy controls. Methods: 16 normal persons and twelve patients with MCI were included in the study. The neurocognitive status was tested by the CERAD-plus test. To investigate spatial orientation ability subjects had to perform a navigation paradigm in a complex unknown spatial environment of an outpatient clinic. The area, in wh…
