STW5 reduces the proinflammatory signature on transcriptomic, proteomic and histological level in a rat model for gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD) was the most common GI-diagnosis (8.9 million visits) in the US in 2012. Although proton pump inhibitors (PPI) represent the treatment of choice, they fail to achieve adequate symptom relief in up to 40% of patients. In the present study, we investigated the modulation of inflammatory markers by STW5 in comparison to the PPI Omeprazole (O) in an animal model of sub-chronic GERD. Rats were pre-treated for 7 d with either STW5 (0.5 or 2 ml/kg) or O (30 mg/kg). Esophagitis was induced surgically, followed by a further 10 d treatment. On day 10, animals were sacrificed and thei…