GRHL1 inhibits tumorigenicity and is a prognostic marker in neuroblastoma
J Fabian, M Lodrini, MC Schier, T Thole, A Kopp-Schneider, D Capper, A von Deimling, I Oehme, I Wiegand, T Milde, F Roels, M Fischer, AE Kulozik, O Witt, HE Deubzer · Klinische Pädiatrie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Inhibition of histone deacetylase activity by small molecules (HDACi) favorably impacts neuroblastoma (NB) biology. Here, we aimed to decipher the underlying molecular mechanisms that have remained enigmatic via gene expression profiling of cell lines in time-course. GRHL1, a highly conserved neuroectodermal developmental transcription factor with no prior defined role in oncology, was among the five strongest immediate early response genes to HDACi treatment. Different HDACi, including those clinically approved, similarly induced GRHL1 expression in a panel of cell lines and NB xenografts in mice, supporting GR…
