Molecular imaging of integrin avb3 for in vivo detection of precursor lesions and pancreatic cancer in mice
M Trajkovic-Arsic, A Sarantopoulos, G Themelis, E Kalideris, AJ Beer, K Pohle, J Wester, RM Schmid, V Ntziachristos, R Braren, J Siveke · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2013 · Heft 04
Bibliografische Angaben
Zusammenfassung
Ziele: Early detection and precise intraoperative delineation of Pancreatic Ductal Adenocarcinoma (PDAC) is urgently needed for improving survival of this otherwise inevitably fatal disease. Methode: By using two avb3 integrin-targeted molecular imaging approaches, Integrisense680 optical imaging and [68Ga]NODAGA-RGD Positron Emission Tomography (PET) imaging, PDAC bearing mice were imaged. Findings were correlated with immunohistological and protein analyses. In additon patient histological samples were analyzed for avb3 integrin expression. Ergebnis: Preneoplastic pancreatic intraepithelial (PanIN) lesions and…