Prevalence of and risk factors for cART-associated drug-induced liver injury (DILI) in HIV/HBV-coinfected, HIV/HCV-coinfected, and HIV-monoinfected patients

Objective: Evaluation of the incidence/prevalence of and risk factors for combined antiretroviral therapy (cART)-associated drug-induced liver injury (DILI) in HIV/HBV-coinfected (HIV/HBV), HIV/HCV-coinfected (HIV/HCV), and HIV-monoinfected patients (HIV). Methods: A total of 267 randomly selected, cART-naïve, HIV/HBV (n = 90), HIV/HCV (n = 90) and HIV (n = 87), who received their first cART at the Medical University of Vienna, were included into this retrospective study. DILI was defined according to the DILI Expert Working Group 2011 criteria, while AIDS Clinical Trials Group 1996 criteria was used for severit…