Characteristic miRNA alterations in adenoma-carcinoma sequence

Background: Many previous studies have revealed abundant knowledge about background of dysregulation in growing, differentiation processes of the tumour cells caused by the alteration of miRNA expression. Recent studies described the changes of the miRNA expression in precancerous lesions and in colorectal cancer. miRNA remain stable in formalin-fixed, paraffin-embedded (FFPE) tissue samples and can be easily isolated. Furthermore their expression pattern can be characteristic to various pathological stages that make them ideal biomarker candidates. Aims:Our primary aim was to identify the miRNA expression alter…