DNA methylation markers of left-sided colorectal cancer based on gene expression screening
B Péterfia, P Hollósi, A Kalmár, O Galamb, S Spisák, B Wichmann, K Tóth, K Leiszter, VÁ Patai, V Kubák, K Kiss, Z Horváth, Z Tulassay, I Kovalszky, B Molnár · Zeitschrift für Gastroenterologie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background and aims: Aberrant DNA methylation can lead to dysregulated expression of certain genes that is proven to contribute to colorectal cancer (CRC) formation and progression. However, our knowledge of the methylation markers of CRC development remains incomplete. Our aims were to identify DNA methylation markers in left-sided CRC samples on the basis of gene expression and to analyze their methylation levels along the colorectal adenoma-carcinoma sequence. Materials and methods: Whole genome expression profiling was performed by using HGU133 Plus 2.0 microarrays (Affymetrix) on healthy colonic (n = 49), c…
