Differential expression of CHL1 Gene in early-onset breast cancer patients and their parents

Introduction: The purpose of this study was to determine a correlation between less expression of CHL1 or deletions close to the CHL1 gene, which might be associated with an elevated risk for breast cancer at a young age. Methods: 50 research subjects recruited to the Washington University/Siteman Cancer Center Young Women's Breast Cancer Program (YWBCP) were selected for study. CGH analyses were undertaken using the NimbleGen 2.1 million oligonucleotide array. The number of copies of the entire genome was compared between the proband and each of her parents to identify potential deletion or amplification in her…