Serum levels of adipokine fibroblast growth factor-21 are increased in preeclampsia
S Schrey, H Stepan, J Richter, LM Hopf, S Kralisch, A Jank, T Ebert, M Blüher, M Stumvoll, M Fasshauer · Geburtshilfe und Frauenheilkunde · 2013 · Heft 06
Bibliografische Angaben
Zusammenfassung
Study question: Proteins secreted from adipocytes – so-called adipokines – influence metabolic and vascular function. Recent data suggest that various adipokines are dysregulated in pre-eclampsia (PE) and might be of pathophysiological and prognostic significance. Fibroblast growth factor (FGF)-21 was recently introduced as a novel adipokine improving glucose metabolism in vitro and in vivo. The question of our study was, whether preeclampsia was associated with altered levels of (FGF)-21 in maternal serum and in the placenta. Methods: We investigated serum FGF-21 levels in patients with PE (n = 51) as compared…
