CareLit Fachartikel
“Pulsed” versus “continuous” application of the prodrug 5-FC for enhancing oncolytic effectiveness of a measles vaccine virus armed with a suicide gene
C Yurttas, S Berchtold, NP Malek, M Bitzer, UM Lauer · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Dokument
1081747
CareLit-ID
Jahr
2013
Publikation
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Metadaten
DOI
ja
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Zusammenfassung
Oncolytic virotherapy with measles vaccine virus (MeV) has already been demonstrated to be safe (Galanis et al., 2010). However, when monitoring the expression of the MeV encoded reporter gene CEA it was found (i) that only few tumor cells were infected by MeV and (ii) that subsequently to initial tumor colonization no substantial production of progeny MeV particles took place in the respective cancer patients (Russell, Peng & Bell, 2012). These early clinical results point out the necessity for an enhancement of oncolytic effectiveness of MeV-based virotherapeutics. In our work, we are developing an armed measl…
Schlagworte
Tumor
After
Cytosine Deaminase
Cytosine
Work
Zeitschrift für Gastroenterologie
