Overcoming oncolysis resistance by double infections with vaccine-derived state-of-the-art virotherapeutics
M Meinhardt, M Zimmermann, J Sturm, NP Malek, M Bitzer, RJ Aguilar, NG Chen, AA Szalay, UM Lauer · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Virotherapy is a promising new approach in cancer therapy. However, in prior work we have identified tumor cell lines originating from colon (HCT-15, KM12) or renal (ACHN) cancer exhibiting a primary resistance towards vaccine-derived virotherapeutics (vaccinia virus, VACV; measles vaccine virus, MeV); variants of both viruses are currently tested in clinical phase I/II trials (e.g., NCT01443260 & NCT00408590). To optimize the outcome of the virotherapeutic treatment we here investigated different schemes of combinatorial applications of recombinant oncolytic viruses of VACV and MeV origin. Aim: Ev…
