Iron overload in cirrhosis is associated to liver insufficiency and circulatory dysfunction but not portal hypertension

Iron overload in liver disease not associated to hemochromatosis is increasingly recognized in cirrhosis. The aim was to evaluate the relationship between iron overload and the main underlying pathophysiological mechanisms of cirrhosis: liver insuffiency and portal hypertension. Methods: All consecutive patients with cirrhosis who underwent hepatic hemodynamic, right heart catheterization and ferritin measurement (within 30 days) were included. Patients were excluded according to the following criteria: active neoplasia (except HCC within Milan), severe COPD, acute event in the previous 2 weeks, immunosuppressio…