Regeneration from acute pancreatitis requires transcriptional silencing of NFATc1

Introduction: Tissue injury initiates a complex regenerative programme ensuring complete restoration of organ structure and function. Understanding the molecular key events in mediation and regeneration from pancreas injury is critical to develop novel therapeutic strategies. Recent evidence suggests important roles for developmental and inflammatory transcription factors in several steps of the regeneration process. Aims: To analyze whether and how the inflammatory transcription factor NFATc1 is involved in the course of acute pancreatitis. Methods: Caerulein and L-Arginin were used to induce acute pancreatitis…