Thyroid dysfunction induced by peginterferon alfa-2b (Peg-2b)/Ribavirin (Rbv) is associated with higher SVR rates in patients with HCV Genotype 1 (G1) infection due to improved ea…
S Mauss, D Hüppe, E Zehnter, MP Manns, G Teuber, T Dahhan, U Meyer, T Witthöft, B Möller, N Dikopoulos, J Brack, B Dreher, D Hartmann, M Bilzer · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: Recently, we have shown that patients (pts) who developed thyroid dysfunction during treatment of HCV G1 infection with peginterferon alfa-2b and ribavirin yielded higher SVR rates. In order to better understand this beneficial effect we investigated the impact of thyroid dysfunction on early virologic response. Methods: Data from pts treated for G1 (N = 1923) infection with Peg2b 1.5 µg/kg/wk + weight-based RBV (800 – 1200 mg/day) for up to 48 wks in a large observational real-life study at 285 sites in Germany were retrospectively analyzed. Thyroid dysfunction was estimated by serum TSH levels. TSH level…
