Effects of surface-modified CBNP on the epithelium of the explanted mouse trachea (CarbonBlack sub-project 3)

The epithelium of the large airways is the first barrier that interacts with environmental (nano-) particles. It also plays a central role to remove inhaled particles through cilia-driven particle transport. The aim of this study was to examine if CBNPs with identical primary particle size but with different surface chemistry have different toxicological effects on the epithelium of the murine trachea. We used the following CBNPs with a primary particle size of 14nm that are either commercially available or were synthesized/modified by CarbonBlack sub-project 1: uncovered CBNPs (Printex®90), CBNPs covered with B…