Vitamin D deficiency in primary sclerosing cholangitis is related to histological fibrosis stage at the time of diagnosis

Background and Aim: There is an emerging interest to explore the relationship between vitamin D deficiency and severity of autoimmune cholestatic diseases, supported by the evidence that vitamin D acts through its own receptor as an important immunomodulator. We therefore aimed to determine serum vitamin D levels in patients with primary sclerosing cholangitis (PSC) and to explore their relation to the histological staging and grading of disease. Methods: Serum-25-hydroxy-vitamin-D (25 OHD) concentrations were measured in 54 patients with PSC within three months of obtaining liver histology. Histological grading…