The impact of adipokines hormones on HCV life-cycle
P Behrendt, J Dörrbecker, E Steinmann, K Hügging, N Menzel, E Grabski, M Rogalska-Taranta, S Pfaender, U Kalinke, H Wedemeyer, MP Manns, T Pietschmann · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Obesity is associated with increased viral load during HCV-infection and non-response to IFN/Ribavirin-based therapy. Fat tissue is known to produce a variety of cytokines and hormones leading to increased levels of pro-inflammatory markers in sera of obese individuals. In this study we assessed the impact of several adipokines on cell-culture derived full-length HCV life cycle. A few tested hormones showed moderate antiviral activity in vitro (IL-6, TNF-α). However, a promising effect was observed for the adipokine Chemerin. Chemerin is a recently discovered hormone that is mainly expressed by fat-tissue and th…
