The involvement of the transcription factor Nrf2 in fetal growth restriction

Objectives: It has been shown that preeclampsia is associated with an increased activity of the transcription factor NF-E2-related factor 2 (Nrf2) within the cytotrophoblast, we recently discussed in vitro a link between Nrf2 and vascular homeostasis. Also early onset IUGR associated with preeclampsia has been associated with impaired invasion of the extravillous trophoblast and dysfunctional Nrf2 signaling. To assess the interaction between Nrf2 signal-transduction pathways and the angiogenesis process, we tested first in vitro the effect of Nrf2 activation on the pro- and anti-angiogenic factors. Then we inves…