Analysis of A. lwoffii-induced proinflammatory signalling and epigenetic changes in splenic CD4+ T cells in an in vitro cell culture model

From epidemiological studies it becomes more and more evident that gene-environment- interactions play an important role in the development of allergic airways disease. It has been shown that the farm-derived A. lwoffii is able to protect against experimental asthma development in mice even in offspring after application to pregnant mother mice. Intranasal application of A. lwoffii leads to a mild acute inflammatory response with influx of neutrophils and increased proinflammatory cytokine (e.g. IL-6, TNFα) production. We hypothesize that A. lwoffii-induced asthma protection works through proinflammatory cytokin…