Additional antidepessant pharmacological options in compliance with the classical neurotransmitters and neuropeptides involved

Introduction: In major depression exist a hypoactivity of the monoamines serotonin, noradrenaline and dopamine, a hyperactivity of the presynaptically inhibitory neurotransmitter GABA and glutamate and alterations of some neuropeptides. A neural network is developed in the midbrain, the hypothalamus and the hippocampus in order to derive additional antidepressant pharmacotherapies. Material/Methods: In the „mood center“ of the midbrain, glutaminergic strongly inhibit via the subtype 5 of the metabotropic glutamate receptors (m5GluR) serotonergic neurons which, partly due to polymorphisms of the serotonin transpo…