Impairment of oscillatory activity in survivors of severe sepsis: a magnetoencephalography study

A number of studies suggest that the clinical manifestation of neurological deficits results from pathologically synchronized neuronal oscillations and altered oscillatory coupling in the brain. For example, aberrant neuronal synchronization was already shown in patients diagnosed with liver cirrhosis. Currently, more and more evidence has been given that former critical care patients, especially survivors of severe sepsis, endure long-lasting cognitive impairments. Sepsis survivors are known to frequently develop an encephalopathy, which is commonly considered as reversible, but profound knowledge is still lack…