Two subgroups of CRLF2-overexpressing pediatric acute lymphoblastic leukemias differ in outcome and gene expression
J Schmäh, S Müller, F Grunz, H Harms, B Rotter, I Koch, G Kahl, P Winter, M Schrappe, M Stanulla, G Cario · Klinische Pädiatrie · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
*These authors contributed similarly to the study. Overexpression of the cytokine receptor-like factor 2 (CRLF2) gene in acute lymphoblastic leukemia (ALL) is caused by different aberrations like a deletion juxtaposing CRLF2 with the P2RY8 promoter, by a translocation involving the immunoglobulin heavy chain locus (IGH@), by supernumerary copies of the CRLF2 locus or by not yet identified causes. However, only the presence of the P2RY8-CRLF2 rearrangement is associated with a high incidence of relapse in CRLF2-overexpressing precursor B-cell ALL (pB-ALL) in children. To investigate the different susceptibility t…
