Innate immune responses and type 1 diabetes: A role for a long non-coding RNA?
MP Ashton, I Tan, L Mackin, C Elso, E Chu, A Papenfuss, B Phipson, G Smyth, M O'Keeffe, S Summers, N Payne, C Bernard, T Brodnicki · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Pattern recognition receptors (PRRs) act as early sensors of microbial pathogens, but accumulating evidence indicates that PRRs also play an important role in autoimmunity. In particular, manipulation of toll-like receptors (TLRs) in the non-obese diabetic (NOD) mouse strain alters the onset of type 1 diabetes (T1D). We have identified a novel gene (Apics), for which sequence variation is associated with T1D incidence in NOD mice. The molecular function of Apics is currently unknown, but we have shown that its expression is upregulated by TLR activation in immune cell subsets. We therefore hypothes…
