Perivascular and subcutaneous adipose tissue differ in internal carotid artery (ACI) Stenosis patients

Background: There is growing evidence for a vasoregulatory and atherosclerosis-inducing role of local fat deposits around vessels. Aim of the study was to investigate gene expression profiles in paired human samples of subcutaneous (sc) and perivascular (pv) adipose tissue (AT) and to link it to clinical and anthropometric characteristics of carotid stenosis patients. Material and methods: A RNA/cDNA bank was established from paired sc (cervical) and pv (ACI) AT samples of patients who underwent carotid endarterectomy. Marker genes e.g. for muscle, fibroblasts or nerve have been measured to control for impuritie…