CareLit Fachartikel
Biological role of the proapoptotic transcription factor C/EBP homologous protein (CHOP) in Idiopathic Pulmonary Fibrosis (IPF)
O Klymenko, I Henneke, C Ruppert, W Seeger, A Guenther, M Korfei · Pneumologie · 2014 · Heft 06
Dokument
1082974
CareLit-ID
Jahr
2014
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
We have recently identified severe and pro-apoptotic Endoplasmic Reticulum (ER) stress as major pathomechanism for alveolar epithelial cell (AEC) injury in Idiopathic Pulmonary Fibrosis (IPF). In line with this, the pro-apoptotic transcription factor CHOP, which functions as a crucial mediator of ER stress-induced apoptosis, was strongly induced in AECII from patients with IPF. We therefore aimed to fully disclose the transcriptional regulation and biological role of epithelial CHOP expression in AECII-like cells in vitro, and in pulmonary fibrosis in vivo. We performed promotor analysis of the human CHOP gene i…
Schlagworte
Apoptosis
Binding Sites
5" Flanking Region
5"-Flanking-Region
A549 Cells
Caspase 3
After
Pneumologie
