Arachidonic acid/cytochrome p450-derived mediators decrease hypoxic pulmonary vasoconstriction in isolated, ventilated and perfused mouse lungs

Introduction: Hypoxic pulmonary vasoconstriction (HPV) is an essential physiological mechanism that adapts perfusion to ventilation to optimize gas exchange by redistributing the blood flow to well-ventilated areas, thereby improving alveolar oxygenation. Disturbances in HPV can lead to life-threatening hypoxemia. Intrinsic and modulatory pathways of HPV are not fully elucidated. Arachidonic acid-derived mediators are known to be potent vasoregulators in different organs in health and disease. In the lung, little is known about the role and physiological function of arachidonic acid/cytochrome p450-derived media…