Generation of Clara cells from murine pluripotent stem cells – a new tool to explore airway epithelial regeneration
K Katsirntaki, C Mauritz, S Schmeckebier, M Sgodda, V Puppe, R Eggenschwiler, J Duerr, SC Schuber, A Schmiedl, M Ochs, I Salwig, M Szibor, T Braus, T Cantz, MA Mall, U Martin · Pneumologie · 2014 · Heft 06
Bibliografische Angaben
Zusammenfassung
Airway epithelial cell production in vitro offers new options to treat airway diseases, including genetic disorders like cystic fibrosis. Pluripotent stem cells (PSCs) (embryonic (ESCs) or induced pluripotent stem cells (iPSCs)) represent a suitable exogenous cell source for cell replacement strategies. Aiming at the long-term restoration of functional airway epithelium, epithelial progenitor/stem cells will be required, e.g. Clara cells. Clara cells are able to regenerate the airway epithelium following injury. With the aim to establish a mouse model of long-term airway epithelial regeneration, we aimed at the…
