Novel alternatively spliced isoform of synuclein gamma

Introduction: Since Synuclein γ (SNCG) is found highly expressed in advanced breast cancer it was initially described as breast-cancer specific gene (BCSG1). Clinical studies demonstrate the correlation of high SNCG expression with advanced stages, metastasis and poor prognosis in breast and ovarian carcinomas, i.e. reduced relapse-free and overall survival periods. In vitro analyses revealed a SNCG-dependent stimulation of ligand-dependent transcriptional activity of ERα. So far, four mRNA isoforms of SNCG were described, but only isoforms-1 and -2 code for active proteins. For the first time, we analyzed expre…